Tacrolimus | 104987-11-3

Tacrolimus, wanda kuma aka sani da sunan kasuwancin sa Prograf da sauransu, magani ne mai ƙarfi na rigakafi wanda aka yi amfani da shi da farko a cikin dashen gabobin don hana ƙin yarda.

Hanyar Aiki: Tacrolimus yana aiki ta hanyar hana calcineurin, furotin phosphatase mai gina jiki wanda ke taka muhimmiyar rawa wajen kunna T-lymphocytes, waɗanda kwayoyin rigakafi ne da ke cikin ƙin yarda. Ta hanyar hana calcineurin, tacrolimus yana toshe samar da cytokines pro-mai kumburi kuma yana hana kunna ƙwayoyin T, ta haka yana danne martanin rigakafi daga sashin da aka dasa.

Alamomi: Ana nuna Tacrolimus don prophylaxis na ƙin yarda da gabobin jiki a cikin marasa lafiya da ke karɓar hanta, koda, ko dashen zuciya. Ana amfani dashi sau da yawa a hade tare da wasu magungunan rigakafi kamar corticosteroids da mycophenolate mofetil.

Gudanarwa: Tacrolimus yawanci ana gudanar da shi ta baki ta hanyar capsules ko maganin baka. Hakanan za'a iya gudanar da shi ta cikin jini a wasu yanayi na asibiti, kamar lokacin lokacin dasawa nan da nan.

Kulawa: Saboda kunkuntar ma'anar warkewa da sauye-sauye a cikin sha, tacrolimus yana buƙatar kulawa da hankali akan matakan jini don tabbatar da ingancin warkewa yayin da yake rage haɗarin haɗari. Kulawa da magungunan warkewa ya haɗa da ma'auni na yau da kullun na matakan jini na tacrolimus da daidaita kashi dangane da waɗannan matakan.

Mummunan Effects: Abubuwan da ke tattare da tacrolimus na yau da kullun sun haɗa da nephrotoxicity, neurotoxicity, hauhawar jini, hyperglycemia, rikicewar gastrointestinal, da ƙari mai saurin kamuwa da cututtuka. Yin amfani da tacrolimus na dogon lokaci na iya ƙara haɗarin haɓaka wasu cututtuka, musamman ciwon daji na fata da lymphoma.

Hanyoyin hulɗar ƙwayoyi: Tacrolimus yana haɓaka da farko ta hanyar tsarin enzyme cytochrome P450, musamman CYP3A4 da CYP3A5. Don haka, magungunan da ke haifar da ko hana waɗannan enzymes na iya shafar matakan tacrolimus a cikin jiki, wanda zai iya haifar da gazawar warkewa ko guba.

Mahimman ra'ayi na musamman: Tacrolimus dosing yana buƙatar keɓancewa bisa dalilai kamar shekarun haƙuri, nauyin jiki, aikin koda, magunguna masu haɗuwa, da kuma kasancewar cututtuka masu haɗari. Kulawa na kusa da bin diddigin yau da kullun tare da ma'aikatan kiwon lafiya suna da mahimmanci don haɓaka jiyya da rage illa.