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Topicastat yana da tasirin hanawa gasa akan xanthine oxidoreductase, don haka yana hana samar da uric acid. Ba shi da wani tasiri mai hanawa akan sauran pyrimidine purine metabolizing enzymes, amma zaɓe yana hana tasirin sinadarai akan xanthine oxidoreductase. Topicastat yana da tasiri mai mahimmanci na hanawa akan duka oxidized da rage XOR, don haka tasirinsa na rage yawan uric acid ya fi karfi da dorewa, don haka ana iya amfani da wannan samfurin don maganin hyperuricemia na kullum a cikin gout.